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SOLUTE CARRIER FAMILY 12, MEMBER 1
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DeCS
Descriptor
English
:
Solute Carrier Family 12, Member 1
Descriptor
Spanish
:
Miembro 1 de la Familia de Transportadores de Soluto 12
Descriptor
Portuguese
:
Membro 1 da Família 12 de Carreador de Soluto
Tree Number:
D12.776.157.530.450.625.750.500
D12.776.543.585.450.625.750.500
Definition
English
:
Na-K-Cl transporter in the ASCENDING LIMB OF
LOOP OF HENLE
. It mediates active reabsorption of
sodium chloride
and is inhibited by LOOP
DIURETICS
such as
FUROSEMIDE
; and
BUMETANIDE
. Mutations in the gene encoding SLC12A1 are associated with a
BARTTER SYNDROME.
See Related
English
:
Bartter Syndrome
History Note
English
:
2014
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AG
agonists
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
CT
contraindications
DF
deficiency
DU
diagnostic use
DE
drug effects
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
SE
secretion
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UL
ultrastructure
UR
urine
Record Number:
55323
Unique Identifier:
D064466
Occurrence in VHL
:
Similar:
DeCS
CID-10
SciELO
LILACS
LIS